6 edition of Biology of the DNA Tumor Viruses (Milestones in Current Research; V. 1) found in the catalog.
December 1, 1976
Written in English
|The Physical Object|
|Number of Pages||273|
What logic suggests that the chromosomal integration of tumor virus genomes is an intrinsic, obligatory part of the replication cycle of RNA tumor viruses but an inadvertent side product of DNA tumor virus . DNA Tumor Viruses In Human Cancer Squamous cell carcinoma: Larynx Esophagus All histologically similar Lung 10% of human cancers may be HPV-linked Papilloma Viruses urogenital cancer wart malignant squamous cell carcinoma Papilloma viruses are found in 91% of women with cervical cancer.
Linking DNA tumor viruses to human cancer Cancer is a multistep process. Over the past three decades it has become increasingly evident that several viruses play a key part in the development of human malignancy. Studies on these oncogenic agents have been instrumental to our understanding of basic cell biology and how pertur-. Since virus spread throughout the tissues of the chicken, the researchers could recover large quantities of the virus Interest in Tumor Viruses Came to a Stand-Still For various reasons, including one discredited study (not Rous's study), the hypothesis that cancer could be caused by infectious agents was to a large extent discarded for ~50 years.
Viruses possess the unusual property of being inert when outside a living cell. However, once they gain access to a living cell, the infective agent – either ribonucleic acid (RNA) or deoxyribonucleic acid (DNA) - commandeers the host cellular machinery to make copies of itself. DNA tumor viruses have long been useful experimental models of carcinogenesis and have elucidated several important mechanisms of cell transformation. Re search in recent years has shown that human tumors have a multifactorial nature and that some DNA tumor viruses may playa key .
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The Biology of DNA Tumor Viruses: With an Introduction by Renato Dulbecco (Milestones in current research): Medicine & Health Science Books @ The Biology of DNA Tumor Viruses With an Introduction by Renato Dulbecco.
Editors; Further Problems in the Biology of Small DNA Viruses. Front Matter. The selections for each volume and the structure of the book have been determined with the help of a novel tech nique of bibliographic analysis and have then been presented to an.
SV40 and Polyomavirus. The best studied DNA tumor viruses, from the standpoint of molecular biology, are probably simian virus 40 (SV40) and gh neither of these viruses is associated with human cancer, they have been critically important as models for understanding the molecular basis of cell utility of these viruses in cancer research has stemmed.
VIII. Further Problems in the Biology of Small DNA Viruses.- 1. Growth Control in Cultured Cells: Selection of Sublines with Increased Sensitivity to Contact Inhibition and Decreased Tumor-Producing Ability.- 2. Mutation Causing Temperature-Sensitive Expression of Cell Transformation by a Tumor Virus.- Author Index.
Series Title. Currently, research on these viruses lies at the interface of cancer and the innate and adaptive immune response, investigating how infectious agents influence, evade, and utilize systems that regulate these processes. Thus, DNA tumor viruses serve as models for the systems biology.
DNA Oncogenic Viruses include the following: The Epstein-Barr virus has been linked to Burkitt’s lymphoma.
This virus infects B cells of the immune system and epithelial cells. The hepatitis B virus has been linked to liver cancer in people with chronic infections.
Human papilloma viruses have been linked to cervical cancer. They also cause. Thus, DNA tumor viruses serve as models for the systems biology of host-pathogen interactions. "DNA Tumor Viruses," edited by Blossom Damania and James M.
Pipas, summarizes recent advances in our understanding of this diverse and fascinating collection of viruses. This book represents a comprehensive review of the field of DNA tumor virology.
Right now, while there are books out there that cover individual viruses that are also covered in this book, there is no single book that covers this topic comprehensively. This book is the first current, comprehensive review of its kind in the market.
Both DNA and RNA viruses have been shown to be capable of causing cancer in humans. Human T lymphotrophic virus type 1 and hepatitis C viruses are the two RNA viruses that contribute to human cancers.
Hepatitis C virus is an enveloped RNA virus capable of causing acute and chronic hepatitis in humans by infecting liver cells. The latter is not typical of most DNA tumor viruses but reverse transcription is a very important factor in the life cycles of RNA-tumor viruses. See below. For more information on the molecular biology of hepatitis B virus and the diseases it causes, go to chapter 18 and chap part 2.
DNA tumor viruses / edited by John Tooze ; [contributors, N.H. Acheson and others] --[pt. RNA tumor viruses / edited by Robin Weiss [and others] ; contributors, A.
Bernstein [and others]. Series Title: Cold Spring Harbor monograph series, 10B. Other Titles: DNA tumor viruses RNA tumor viruses. The book concludes by evaluating the possibility of direct etiologic involvement of either endogenous or exogenous RNA tumor viruses in human cancers.
This book will be of value both to graduate students and to established investigators with specific interest in other aspects of molecular biology. DNA tumor viruses. Molecular biology of tumor viruses, 2nd edition, Part 2 J. Tooze, ed. New York: Cold Spring Harbor Laboratory.
$ Together, DNA viruses have been estimated to be responsible for million new cases of cancer worldwide inwith two viruses baring 85% of this burden: human papillomavirus ( cases worldwide), and hepatitis B virus ( cases). Wang-Shick Ryu, in Molecular Virology of Human Pathogenic Viruses, Tumor viruses have served as an excellent experimental model for cancer research since the s.
A representative epitome is that the discoveries of the oncogene 1 and the tumor suppressor gene 2 were achieved by the investigation of tumor viruses.
Tumor viruses could induce not only transformation 3 of cells in. DNA Tumor Viruses. Whereas the study of RNA tumor viruses was largely responsible for the discovery of oncogenes, the study of DNA tumor viruses led to the discovery and elucidation of the function of cellular tumor suppressor genes, most notably p53 and pRb.
Much of the initial knowledge about DNA tumor viruses came from the study of SV40, a. Since RNA makes up the genome of the mature virus particle, it must be copied to DNA prior to integration into the host cell chromosome.
This life style (figure 10) goes against the central dogma of molecular biology in which that DNA is copied into RNA.
RNA tumor viruses or oncornaviruses are members of the retrovirus family. Retrovirus structure. Key Takeaways Key Points. Both DNA and RNA viruses have been shown to be capable of causing cancer in humans.
Epstein-Barr virus, human papilloma virus, hepatitis B virus, and human herpes virus-8 are the four DNA viruses that are capable of causing the development of human cancers. This book serves as an excellent text in comparative virology, with an up-to-data overview and detail for each group of DNA tumor viruses.
The authors review the common and diverse mechanisms of action of the transforming proteins of DNA tumor viruses. DNA Tumor Viruses will focus on the DNA viruses in the human population that are associated with cancers.
It will cover most of the viruses that are thought to contribute to human book will represent a comprehensive review of the field of DNA tumor virology. Right now, while there are books out there that cover individual viruses that will be also. This summer marks the 51st anniversary of the DNA tumor virus meetings.
Scientists from around the world will gather in Trieste, Italy, to report their latest results and to agree or disagree on the current concepts that define our understanding of this diverse class of viruses.
This article offers .Many, But Not All, Cancer-Causing Agents Damage DNA. The agents that can cause cancer are many and varied, but the easiest to understand are those that cause damage to DNA, and so generate cancer-causing mutagens include chemical carcinogens, viruses, and various forms of radiation—UV light and ionizing radiation such as gamma rays and alpha particles from radioactive .Tumor viruses and cancer biology Modulating signaling pathways a DNA virus which integrates into the host DNA and directly transforms hepatocytes.9 The role for integration in transforma.